Angiotensin II Type 1–Receptor Activating Antibodies in Renal-Allograft Rejection

Angiotensin II Type 1–Receptor Activating Antibodies in Renal-Allograft Rejection

Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection.

BACKGROUND Antibodies against HLA antigens cause refractory allograft rejection with vasculopathy in some, but not all, patients. METHODS We studied 33 kidney-transplant recipients who had refractory vascular rejection. Thirteen had donor-specific anti-HLA antibodies, whereas 20 did not. Malignant hypertension was present in 16 of the patients without anti-HLA antibodies, 4 of whom had seizur...

Investigation of Serum Angiotensin II Type 1 Receptor Antibodies at the Time of Renal Allograft Rejection

BACKGROUND Angiotensin II type 1 receptor (AT1R) is responsible for cardiovascular effects mediated by angiotensin II. This study aimed to investigate the impact of antibodies directed against AT1R (anti-AT1R) in renal allograft rejection. METHODS We evaluated 53 patients who had biopsy-proven rejection including antibody-mediated rejection (AMR) (N=22), T-cell-mediated rejection (TCMR) (N=29...

The Presence of Anti-Angiotensin II Type-1 Receptor Antibodies Adversely Affect Kidney Graft Outcomes

The aim of this study was to determine whether anti-angiotensin type 1 receptor antibodies (AT1R-Abs) are related to acute rejection (AR) and kidney graft failure in renal transplantation. We searched electronic databases including MEDLINE, EMBASE, and the ISI Web of Science databases for all studies on the association between anti-angiotensin type 1 receptor antibodies and kidney allograft out...

Non-HLA Antibody Induced Agonism on the Angiotensin II Type 1 Receptor in Renal Allograft Vascular Injury

The rising incidence of steroid-refractory rejections is a challenging problem in renal allotransplantation. Etiological studies implicate either an overwhelming T-cell response or, more frequently, involvement of alloantibodies. Alloantibodies induce a spectrum of histologic tubulointerstitial and vascular changes paralleled with immunohistochemical positivity for C4d along peritubular capilla...